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Ncoa6 Gene Detail
Summary
  • Symbol
    Ncoa6
  • Name
    nuclear receptor coactivator 6
  • Synonyms
    AIB3, ASC-2, ASC2, mKIAA0181, NRC, PRIP, RAP250
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929915
    NCBI Gene: 56406
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:155232585-155315741 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 77.26 cM, cytoband H2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1289 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929915
 protein coding gene Chr2:155232576-155315814 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026734
 protein coding gene Chr2:160207075-160295320 (-)
A/J MGP_AJ_G0026700
 protein coding gene Chr2:153839767-153927908 (-)
AKR/J MGP_AKRJ_G0026671
 protein coding gene Chr2:158303864-158395283 (-)
BALB/cJ MGP_BALBcJ_G0026709
 protein coding gene Chr2:154141466-154226568 (-)
C3H/HeJ MGP_C3HHeJ_G0026452
 protein coding gene Chr2:158661714-158750983 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027158
 protein coding gene Chr2:164901382-165001050 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024528
 protein coding gene Chr2:147342497-147426612 (-)
CAST/EiJ MGP_CASTEiJ_G0025913
 protein coding gene Chr2:158970453-159067603 (-)
CBA/J MGP_CBAJ_G0026429
 protein coding gene Chr2:170900064-170995841 (-)
DBA/2J MGP_DBA2J_G0026566
 protein coding gene Chr2:153022688-153109359 (-)
FVB/NJ MGP_FVBNJ_G0026533
 protein coding gene Chr2:151403605-151486747 (-)
LP/J MGP_LPJ_G0026671
 protein coding gene Chr2:160349096-160445461 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026554
 protein coding gene Chr2:174902435-174990990 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027214
 protein coding gene Chr2:158192425-158282172 (-)
PWK/PhJ MGP_PWKPhJ_G0025647
 protein coding gene Chr2:152524066-152607811 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025450
 protein coding gene Chr2:157116918-157208051 (-)
WSB/EiJ MGP_WSBEiJ_G0025983
 protein coding gene Chr2:159079495-159165698 (-)



Homology
more
  • Human Ortholog
    NCOA6, nuclear receptor coactivator 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NCOA6, nuclear receptor coactivator 6
  • Synonyms
    AIB3, ASC2, NRC, PRIP, RAP250, TRBP
  • Links
    NCBI Gene ID: 23054
    neXtProt AC: NX_Q14686
    UniProt: Q14686

  • Chr Location
    20q11.22; chr20:34689097-34825651 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ncoa6 mouse models; 3 with human NCOA6 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    110 phenotypes from 9 alleles in 12 genetic backgrounds
    1 phenotype from multigenic genotypes
    11 images
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit retarded embryonic growth and defects of the placenta, heart, liver, and nervous system. Mutants die around midgestation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    999
  • Tissues
    185
  • cDNA Data
    183
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56406 NCBI Gene Model | MGI Sequence Detail 83157 C57BL/6J ±  kb
    transcript NM_019825 RefSeq | MGI Sequence Detail 7116 C57BL/6  
    polypeptide Q9JL19 UniProt | EBI | MGI Sequence Detail 2067 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 188
      Genomic 1
      cDNA 183
      Primer pair 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1355304
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 12
      Phenotypes 27
    • Earliest
      J:60556 Caira F, et al., Cloning and characterization of RAP250, a novel nuclear receptor coactivator. J Biol Chem. 2000 Feb 25;275(8):5308-17
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory